Evidence-Based, Personalized Treatment for Women
What Are Perimenopause and Menopause?
Perimenopause is the transitional phase leading up to menopause, often beginning in a woman’s late 30s or 40s. During this time, estrogen and progesterone levels fluctuate unpredictably, leading to physical, emotional, and metabolic changes.
Menopause is defined as 12 consecutive months without a menstrual period and typically occurs around age 51. Hormone levels stabilize at lower levels, but symptoms — and health risks — can persist for years without proper management.
These transitions are biological, not psychological. Unfortunately, many women are under-diagnosed or told their symptoms are “normal,” without being offered effective, evidence-based treatment.
Symptoms can begin years before periods stop and vary widely between women.
Common Symptoms & Changes
Physical Symptoms
- Hot flashes and night sweats
- Weight gain or increased abdominal fat
- Fatigue and low energy
- Difficulty sleeping
- Hair thinning or hair loss
- Joint and muscle aches
- Headaches or migraines
Metabolic & Body Composition Changes
- Increased insulin resistance
- Difficulty losing weight despite diet and exercise
- Loss of lean muscle mass
- Changes in cholesterol and blood sugar
Mood & Cognitive Changes
- Anxiety or panic symptoms
- Mood swings or irritability
- Brain fog or difficulty concentrating
- Low motivation or depressive symptoms
Reproductive & Sexual Health Changes
- Irregular periods (perimenopause)
- Vaginal dryness or discomfort
- Decreased libido
- Pain with intercourse
Our Approach
At Physicians Premiere, we focus on medical, personalized, and data-driven care — not one-size-fits-all solutions.
Hormone therapy works by replacing or stabilizing hormones that naturally decline or fluctuate during perimenopause and menopause. When prescribed appropriately, it is the most effective treatment for many symptoms and has well-documented safety and long-term health benefits.
You Don’t Have to “Just Live With It”
Early, proactive treatment can:
- Improve daily quality of life
- Support metabolic and bone health
- Reduce long-term health risks
- Help women feel like themselves again
Available Hormone Therapies
Estrogen - The cornerstone of menopause treatment
Helpful for:
- Hot flashes and night sweats
- Sleep disruption related to vasomotor symptoms
- Vaginal dryness and genitourinary symptoms
- Mood symptoms related to hormonal fluctuation
- Bone loss and fracture risk
Forms:
- Oral estrogen
- Transdermal estrogen (patch, gel, spray)
- Vaginal estrogen (cream, tablet, ring — local therapy only)
Evidence:
- Most effective treatment for vasomotor symptoms
- Reduces risk of osteoporosis and fractures
- Favorable cardiovascular profile when started in appropriate patients under age 60 or within 10 years of menopause
Progesterone
Helpful for:
- Any woman with a uterus using systemic estrogen
- Protecting the uterine lining from estrogen-induced hyperplasia
- Improving sleep quality
- Reducing anxiety and mood instability in some patients
Forms:
- Oral micronized progesterone
- Combination estrogen-progestin therapy
- Intrauterine progesterone devices (off-label in select cases)
Evidence:
- Required for safety when estrogen is used in women with a uterus
- Micronized progesterone is associated with better sleep and fewer metabolic side effects than synthetic progestins
Testosterone for Women
Helpful for:
- Low libido
- Persistent fatigue or low motivation (after other causes are excluded)
- Reduced sense of well-being in select patients
Forms:
- Low-dose transdermal preparations
Evidence:
- Strong evidence supports testosterone therapy for treatment of low libido in postmenopausal women